Dr. Joanne Magro “The Power of the Stiletto.” News Column (012)

Edition Twelve- Week Twelve; News Column:

Written by: Dr. Joanne Magro 

Addressing Mental Health Issues for our Veterans We can do better What you need to know about Psychedelic Treatment

Psychedelic Treatment for Post Traumatic Stress Disorder- CONTROVERSY

MDMA- Assisted Therapy

MAPS Study (Multidisciplinary Association for Psychedelics Studies): One of the most significant studies involves MDMA (commonly known as ecstasy) combined with psychotherapy. In Phase 3 trials, it was found that participants who received MDMA showed significant reductions in PTSD symptoms compared to those who received placebo.

Results: In one study, approximately 67% of participants who underwent MDMA therapy experienced a clinically significant reduction in symptoms, with many no longer meeting the criteria for PTSD after treatment.

Johns Hopkins University Study: This research investigated the effects of psilocybin, the active compound in magic mushrooms, on individuals with treatment-resistant depression and anxiety, which are often related to PTSD. While not exclusively focused on veterans, it provides valuable insights.

Findings: Participants who received higher doses of “magic mushrooms” reported significant changes in mood and cognition, with lasting effects on their mental well-being. This suggests psilocybin may help reframe traumatic experiences.

Ketamine Studies

Although not a classic psychedelic, ketamine has shown promise in PTSD treatment and is often discussed in this context. Studies have demonstrated its ability to quickly reduce suicidal thoughts and PTSD symptoms.

Example Study: Research found that patients experienced rapid relief from symptoms following infusions, suggesting a different mechanism that may be beneficial for those with chronic PTSD.

Follow- Up Research

Ongoing studies continue examine the long-term effects of psychedelic treatments for PTSD. Researchers are interested in not just symptom reduction but also improvements in overall life satisfaction and functioning.

Safety and Efficacy:

Researchers are also focused on ensuring that these therapies are conducted safely and

effectively, particularly in populations with past trauma.

Considerations

Therapeutic Environment: Studies emphasize that the setting and accompanying psychotherapy are crucial components of these treatments.

Regulation and Accessibility:

While results are promising, these substances remain regulated, and more legislative changes are needed to ensure wider access for veterans seeking help.

These studies indicate a growing interest in using psychedelics to assist veterans in using psychedelics to assist veterans with PTSD, pointing to a potential shift in how mental health treatments are approached. Research expands; more veterans could benefit from these innovative therapies.

Safety Profile:

The study found that MDMA had a favorable safety profile when used in a controlled therapeutic setting. Most participants experienced manageable side effects, such as temporary increases in blood pressure and mild psychological distress.

Long Lasting Effects

Improvements in PTSD symptoms were found to be stable over time. Follow-up assessments showed sustained symptom relief months after the therapy sessions.

Participant Experiences:

Participants reported transformative experiences during the therapies, often describing feelings of connectiveness, emotional release, and enhanced insight into their trauma, which contributed to their healing process.

Neurochemical Changes:

The substance increases the release of serotonin, dopamine, and oxytocin in the brain. This can lead to improved mood, decreased anxiety, and a heightened sense of empathy and connection with others.

Regulatory Advances:

The MAPS study is instrumental in the push for reclassifying MDMA for therapeutic use. The promising results have contributed to advocating for MDMA as an approved treatment for PTSD.

Therapeutic Setting:

Controlled Environment:

MDMA therapy typically takes place in a safe, comfortable setting, guided by trained therapists. This environment helps individuals feel secure and supports their emotional journey.

Preparation and Integration:

Before the MDMA session, participants undergo preparatory sessions with therapists. Afterwards, they also have integration sessions to discuss their experiences and how to apply insights gained during the therapy.

The Therapy Sessions:

Session Structure: During the MDMA session, which can last several hours, participants consume the substance in a clinical setting. Therapists support and guide them as they explore their memories, emotions and trauma.

Exploration of the Trauma:

The effects of MDMA can allow patients to revisit traumatic experiences without overwhelming anxiety. This lets them process these events in a new, less distressing way, often leading to breakthroughs and insights.

Post- Therapy Effects:

Integration of Experience:

Following the sessions, participants work with their therapists to integrate their experiences and insights into their daily lives. This may involve developing coping strategies and new perspectives on their trauma.

Long-Term Impact:

Research shows that the therapeutic benefits can have lasting effects, leading to sustained

improvements in PTSD symptoms and overall mental health. Take-Aways:

Enhanced Emotional Processing:

Increased Emotional Access: MDMA facilitates emotional expression and allows individuals to confront painful memories more easily. This can lead to breakthroughs in understanding and processing their trauma.

Reduction of Anxiety and Fear:

Lessening Psychological Barriers: This substance helps reduce anxiety and fear associated with traumatic memories. This reduction enables individuals to engage more fully in therapy and discuss difficult topics without overwhelming distress.

Strengthened Therapeutic Alliance:

Increased Trust and Connection: MDMA can foster feelings of trust and safety, enhancing the rapport between the therapist and the participant. This supportive relationship is critical for effective therapy.

Memory Reconsolidation:

Transformative Experiences: By creating a safe context for revisiting trauma, MDMA therapy can help individuals recontextualize their traumatic memories, potentially changing how these memories are stored in the brain and reducing their emotional charge.

Rapid Symptom Relief: Quick Impact: Many participants in clinical studies report noticeable improvements in PTSD symptoms shortly after a few MDMA-assisted therapy sessions, compared to traditional therapies that may take longer to show effects.

Psychological Insight:

Deeper Self-understanding:

Participants often report gaining valuable insights into their thoughts, feeling, and behaviors during the sessions. These realizations may lead to personal growth and help individuals change negative thought patterns.

Hope for Treatment- Resistant Cases:

Alternative for those who have tried other treatments. MDMA therapy is promising for individuals who have not responded well to traditional therapies, offering a new and hopeful avenue for healing.

Overall, the MAPS study indicated that MDMA-assisted therapy could be a powerful tool in treating PTSD among veterans and others suffering from trauma, highlighting the potential for new avenues in mental health care. In addition, MDMA therapy presents a unique approach to treating PTSD and other mental health conditions by leveraging the therapeutic properties of the substance in a controlled environment. As research continues to develop. The understanding of its benefits and potential applications in mental health treatment may expand further.

“The Doctor Joanne Magro Foundation for Physician Health and Wellness”/ jmagromd@gmail.com and Peer Support Specialist for Addiction Recovery and Support Community Outreach/ jmagromd@gmail.com.

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